Indazolinone → 3-Oxo-3H-indazole-1,2-dicarboxylic acid bis(2-methylbenzylamide)

反応式

[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([OH:10])=[N:2]1.[N:11]([CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[CH3:21])=[C:12]=[O:13]>>[CH3:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[CH2:14][NH:11][C:12]([N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](=[O:10])[N:2]1[C:12]([NH:11][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[CH3:21])=[O:13])=[O:13]

参加物

反応物 2

HCID 81829Indazolinone

HCID 27333861-(Isocyanatomethyl)-2-methylbenzene

生成物 1

HCID 684583883-Oxo-3H-indazole-1,2-dicarboxylic acid bis(2-methylbenzylamide)

実験手順

In analogy to example 11, 300 mg (2.24 mmol) of 1H-indazol-3-ol were reacted with 395.5 mg (2.69 mmol) of 1-isocyanatomethyl-2-methylbenzene. Yield: 177 mg (18%), M+H+: 429.26.

出典と根拠

ORDレコード: ord-e7ae1b7aa43246d2903d382f859acc0d
出典データセット: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07772268B2

反応ノート

読み込み中…