(7R,7aS)-4-(7-Hydroxy-1,3-dioxotetrahydropyrrolo[1,2-c]imidazol-2-yl)-5,6,7,8-tetrahydronaphthalene-1-carbonitrile → (7R,7aS)-5-(7-Hydroxy-1,3-dioxotetrahydropyrrolo[1,2-c]imidazol-2-yl)-quinoline-8-carbonitrile

HRID 501542

反応式

HRID 501542 の反応式
[N+:1]([C:4]1[CH:13]=[CH:12][C:11]([C:14]#[N:15])=[C:10]2[C:5]=1[CH:6]=[CH:7][CH:8]=[N:9]2)([O-])=O.C1C2C(=C(NC(=O)C)C=CC=2)CC1.N(C1C2CCCCC=2C(C#N)=CC=1)=C=O.[OH:44][C@H:45]1[C@@H:52]2[N:48]([C:49](=[O:66])N(C3C4CCCCC=4C(C#N)=CC=3)[C:51]2=[O:53])[CH2:47][CH2:46]1>>[OH:44][C@H:45]1[C@@H:52]2[N:48]([C:49](=[O:66])[N:1]([C:4]3[CH:13]=[CH:12][C:11]([C:14]#[N:15])=[C:10]4[C:5]=3[CH:6]=[CH:7][CH:8]=[N:9]4)[C:51]2=[O:53])[CH2:47][CH2:46]1

参加物

5

反応物 4

HCID 9904811(7R,7aS)-4-(7-Hydroxy-1,3-dioxotetrahydropyrrolo[1,2-c]imidazol-2-yl)-5,6,7,8-tetrahydronaphthalene-1-carbonitrileHCID 12683814N-(2,3-Dihydro-1H-inden-4-yl)acetamideHCID 218748385-Nitroquinoline-8-carbonitrileHCID 597543044-Isocyanato-5,6,7,8-tetrahydronaphthalene-1-carbonitrile

生成物 1

HCID 59754313(7R,7aS)-5-(7-Hydroxy-1,3-dioxotetrahydropyrrolo[1,2-c]imidazol-2-yl)-quinoline-8-carbonitrile

実験手順

The title compound was synthesized from compound 12C by procedures analogous to those described in Experiment 3A and Experiment 2 (2E to 2F). 99.8% at 2.05 min (retention time) (Conditions: YMC S5 ODS (4.6×50 mm); Eluted with 0% to 100% B; 4 min gradient; (A=90% H2O-10% MeOH-0.1% H3PO4 and B=10% H2O-90% MeOH-0.1% H3PO4); Flow rate at 4 mL/min. UV detection at 220 nm). LC/MS nm/z 309 [M+H]+.

後処理

  1. washEluted with 0% to 100% B
  2. custom4 min gradient

出典と根拠

ORDレコード
ord-361cbb36f79d4a8d8173a37d88efb6fb
出典データセット
uspto-grants-2010_08
特許番号
US07772267B2

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