Potassium Carbonate → 6-Nitroquinolin-2(1H)-one

HRID 501578ノート

反応式

HRID 501578 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[C:9]([O:14]C(=O)C)[CH:8]=[CH:7]2)([O-:3])=[O:2].C([O-])([O-])=O.[K+].[K+]>CO>[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH:8]=[CH:7]2)([O-:3])=[O:2]

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 597542506-Nitro-2-acetoxyquinoline

生成物 1

HCID 8999326-Nitroquinolin-2(1H)-one収率 94.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Compound 46A (210 mg, 0.90 mmol) was dissolved in MeOH (10 mL), K2CO3 was added, and the reaction was stirred at rt for 30 min. The reaction was then concentrated under reduced pressure and subsequently purified by silica gel flash chromatography eluting with 5-10% MeOH/CH2Cl2 (gradient) to give the title compound (162 mg, 94%) as a pink solid. LC/MS m/z 191 [M+H]+.

後処理

  1. concentrationThe reaction was then concentrated under reduced pressure
  2. customsubsequently purified by silica gel flash chromatography
  3. washeluting with 5-10% MeOH/CH2Cl2 (gradient)

出典と根拠

ORDレコード
ord-2bf9cc19f3094f8f8fc0e215360b910e
出典データセット
uspto-grants-2010_08
特許番号
US07772267B2

反応ノート

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