Bromine → N-(4-Bromo-3-fluoro-2-methylphenyl)acetamide

HRID 501631ノート

反応式

HRID 501631 の反応式
[F:1][C:2]1[C:3]([CH3:12])=[C:4]([NH:8][C:9](=[O:11])[CH3:10])[CH:5]=[CH:6][CH:7]=1.[Br:13]Br>C(O)(=O)C>[Br:13][C:7]1[CH:6]=[CH:5][C:4]([NH:8][C:9](=[O:11])[CH3:10])=[C:3]([CH3:12])[C:2]=1[F:1]

参加物

4

反応物 2

HCID 24408BromineHCID 1489284N-(3-fluoro-2-methylphenyl)acetamide

生成物 1

HCID 67123438N-(4-Bromo-3-fluoro-2-methylphenyl)acetamide収率 90%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a solution of N-(3-fluoro-2-methylphenyl)acetamide (72A) (1.71 g, 10.2 mmol) in acetic acid (15 mL) at 0° C. was added bromine (1.68 mL, 32.8 mmol) over 15 min. The mixture was stirred at rt for 2 h, and was then poured into ice (50 g). The mixture was filtered and concentrated under reduced pressure to give the title compound (2.26 g). LCMS: m/z 246[M+H]+

後処理

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-4c0ed42126dc4f718369c4ec53fa196e
出典データセット
uspto-grants-2010_08
特許番号
US07772267B2

反応ノート

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