(S)-methyl 2-(3-ethoxy-N-methylthiophene-2-carboxamido)pent-4-enoate → (s)-2-(3-Ethoxy-n-methylthiophene-2-carboxamido)pent-4-enoic acid

HRID 501678ノート

反応式

HRID 501678 の反応式
FC(F)(F)CCS(N([C@@H](CCC=C)C(OC)=O)C)(=O)=O.[CH2:21]([O:23][C:24]1[CH:28]=[CH:27][S:26][C:25]=1[C:29]([N:31]([C@@H:33]([CH2:38][CH:39]=[CH2:40])[C:34]([O:36]C)=[O:35])[CH3:32])=[O:30])[CH3:22]>>[CH2:21]([O:23][C:24]1[CH:28]=[CH:27][S:26][C:25]=1[C:29]([N:31]([C@@H:33]([CH2:38][CH:39]=[CH2:40])[C:34]([OH:36])=[O:35])[CH3:32])=[O:30])[CH3:22]

参加物

3

反応物 2

HCID 68466211(S)-methyl 2-(3-ethoxy-N-methylthiophene-2-carboxamido)pent-4-enoateHCID 86622317(S)-methyl 2-(3,3,3-trifluoro-N-methylpropylsulfonamido)hex-5-enoate

生成物 1

HCID 59423696(s)-2-(3-Ethoxy-n-methylthiophene-2-carboxamido)pent-4-enoic acid収率 89%

実験手順

Step N (2): Same procedure as Step A (3). (S)-Methyl 2-(3,3,3-trifluoro-N-methylpropylsulfonamido)hex-5-enoate from Step N (1) was subjected to the ester hydrolysis protocol. The procedure provided 68 mg (89% yield) of the title compound as a colorless oil. LC-MS (M+H)+=284.27.

出典と根拠

ORDレコード
ord-4bd6422535584fabae824eac88d5eac9
出典データセット
uspto-grants-2010_08
特許番号
US07772221B2

反応ノート

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