Ethyl orthoformate → HCID 15114404、化合物

HRID 501717

反応式

HRID 501717 の反応式
[Br:1][C:2]1[CH:9]=[CH:8][C:7](C(F)(F)F)=[CH:6][C:3]=1C=O.[OH2:14].[C:15]1(C)C=CC(S(O)(=O)=O)=CC=1.C(O[CH:29]([O:33][CH2:34]C)[O:30][CH2:31]C)C>CO>[Br:1][C:2]1[CH:9]=[CH:8][C:7]([O:14][CH3:15])=[CH:6][C:3]=1[CH:29]([O:30][CH3:31])[O:33][CH3:34]

参加物

5

反応物 3

HCID 31214Ethyl orthoformateHCID 521998p-Toluenesulfonic acid monohydrateHCID 70180472-Bromo-5-(trifluoromethyl)benzaldehyde

生成物 1

HCID 15114404HCID 15114404、化合物収率 71%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Step AJ (1): 2-Bromo-5-(trifluoromethyl)benzaldehyde (1069 mg, 4.975 mmol) was dissolved in a mixture of methanol (20 mL) and triethylorthoformate (20 mL). p-Toluenesulfonic acid monohydrate (180.0 mg, 0.946 mmol) was added and the reaction mixture was stirred under reflux for 5 h. The reaction was quenched with aqueous NaHCO3 and extracted with DCM. The combined organic phases were dried over Na2SO4, filtered and concentrated in vacuum at the temperature, not exceeding 35° C. The residue was purified by silica gel chromatography to give 1-bromo-2-(dimethoxymethyl)-4-methoxybenzene (1060 mg, 71%) as a colorless oil. LC-MS (M−OCH3)+=267.23.

後処理

  1. temperatureunder reflux for 5 h
  2. customThe reaction was quenched with aqueous NaHCO3
  3. extractionextracted with DCM
  4. dry with materialThe combined organic phases were dried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated in vacuum at the temperature
  7. customexceeding 35° C
  8. customThe residue was purified by silica gel chromatography

出典と根拠

ORDレコード
ord-25ca6c9a1559491c99e95eb8418e6fef
出典データセット
uspto-grants-2010_08
特許番号
US07772221B2

関連ノート

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