Hydrochloric Acid → 2-(4-Aminophenoxy)acetic acid hydrochloride

HRID 501830

反応式

HRID 501830 の反応式
C([O:3][C:4](=[O:17])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13]C(=O)C)=[CH:9][CH:8]=1)C.[ClH:18]>>[ClH:18].[NH2:13][C:10]1[CH:9]=[CH:8][C:7]([O:6][CH2:5][C:4]([OH:17])=[O:3])=[CH:12][CH:11]=1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 309738Ethyl 2-(4-acetamidophenoxy)acetate

生成物 1

HCID 668114882-(4-Aminophenoxy)acetic acid hydrochloride収率 77.6%

反応条件

温度
10 °C

実験手順

(4-Acetylamino-phenoxy)-acetic acid ethyl ester 1 (375 grams, 1.582 mmol), in concentrated Hydrochloric acid (9.36 liters) was refluxed for 12 Hours. Excess concentrated Hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 2(250 g, 77.6%) as a wheat colored powder.

後処理

  1. distillationExcess concentrated Hydrochloric acid was distilled off in vacuum
  2. filtrationfiltered hot
  3. filtrationfiltered
  4. customdried

出典と根拠

ORDレコード
ord-88965aaa5e764a9a987fed00cee01d87
出典データセット
uspto-grants-2010_08
特許番号
US07772352B2

関連ノート

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