6-(4-Nitrophenoxy)-hexanoic acid methyl ester → 6-(4-Nitrophenoxy)hexanoic acid

HRID 501852

反応式

HRID 501852 の反応式
C[O:2][C:3](=[O:19])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][CH:11]=1>Cl>[N+:16]([C:13]1[CH:12]=[CH:11][C:10]([O:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3]([OH:19])=[O:2])=[CH:15][CH:14]=1)([O-:18])=[O:17]

参加物

3

反応物 1

HCID 146502956-(4-Nitrophenoxy)-hexanoic acid methyl ester

生成物 1

HCID 223889056-(4-Nitrophenoxy)hexanoic acid収率 80.2%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

6-(4-nitrophenoxy)-hexanoic acid methyl ester 21 (125 g, 468.16 mmol) was refluxed in conc. HCl (1250 ml) for 16 hours. The reaction mixture was cooled to room temp., filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:6) to get pure 35 (95 g, 80.2%) as a white powder with an m.p. between 104-107° C.

後処理

  1. temperatureThe reaction mixture was cooled to room temp.
  2. filtrationfiltered
  3. customdried
  4. customrecrystallised from a mixture of ethyl acetate:hexane (1:6)

出典と根拠

ORDレコード
ord-d1fe644fb5cc4660bc8da73d040dcbd9
出典データセット
uspto-grants-2010_08
特許番号
US07772352B2

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