Quinoline-6-carbonyl chloride → N-(3-dimethylaminophenyl)-4-methyl-3-(6-quinolylcarbonylamino)benzamide

HRID 502038ノート

反応式

HRID 502038 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11](Cl)=[O:12])=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[NH2:14][C:15]1[CH:16]=[C:17]([CH:30]=[CH:31][C:32]=1[CH3:33])[C:18]([NH:20][C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([N:27]([CH3:29])[CH3:28])[CH:22]=1)=[O:19]>>[CH3:29][N:27]([CH3:28])[C:23]1[CH:22]=[C:21]([NH:20][C:18](=[O:19])[C:17]2[CH:30]=[CH:31][C:32]([CH3:33])=[C:15]([NH:14][C:11]([C:7]3[CH:6]=[C:5]4[C:10](=[CH:9][CH:8]=3)[N:1]=[CH:2][CH:3]=[CH:4]4)=[O:12])[CH:16]=2)[CH:26]=[CH:25][CH:24]=1

参加物

3

反応物 2

HCID 12391963Quinoline-6-carbonyl chlorideHCID 226361113-amino-N-(3-dimethylaminophenyl)-4-methylbenzamide

生成物 1

HCID 9802441N-(3-dimethylaminophenyl)-4-methyl-3-(6-quinolylcarbonylamino)benzamide

実験手順

Using an analogous procedure to that described in Example 2, 6-quinolylcarbonyl chloride was reacted with 3-amino-N-(3-dimethylaminophenyl)-4-methylbenzamide to give the title compound; NMR Spectrum: (DMSOd6) 2.35 (s, 3H), 2.91 (s, 6H), 6.58 (m, 1H), 7.2 (m, 2H), 7.43 (d, 1H), 7.65 (m, l1H), 7.82 (d, 1H), 8.01 (s, l1H), 8.17 (m, 2H), 8.32 (d, 1H), 8.59 (d, 1H), 8.7 (d, 1H), 9.02 (s, 1H), 10.05 (s, 1H), 10.32 (s, 1H); Mass Spectrum: M+H+425.

出典と根拠

ORDレコード
ord-78893fd977b24b059299b7444415623c
出典データセット
uspto-grants-2010_08
特許番号
US07772432B2

反応ノート

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