2,4-Dimethylbenzoic acid → N-[1-(4-Chloro-3-ethoxy-benzyl)piperidin-4-yl]-2,4-dimethyl-benzamide

HRID 502348

反応式

HRID 502348 の反応式
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH:10]([NH2:13])[CH2:9][CH2:8]2)=[CH:4][C:3]=1[O:16][CH2:17][CH3:18].[CH3:19][C:20]1[CH:28]=[C:27]([CH3:29])[CH:26]=[CH:25][C:21]=1[C:22](O)=[O:23]>>[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH:10]([NH:13][C:22](=[O:23])[C:21]3[CH:25]=[CH:26][C:27]([CH3:29])=[CH:28][C:20]=3[CH3:19])[CH2:9][CH2:8]2)=[CH:4][C:3]=1[O:16][CH2:17][CH3:18]

参加物

3

反応物 2

HCID 118972,4-Dimethylbenzoic acidHCID 592103771-(4-Chloro-3-ethoxybenzyl)piperidin-4-ylamine

生成物 1

HCID 68454779N-[1-(4-Chloro-3-ethoxy-benzyl)piperidin-4-yl]-2,4-dimethyl-benzamide収率 8%

実験手順

The title compound (3 mg, 8%) was prepared analogously to example 8 by coupling of 1-(4-chloro-3-ethoxy-benzyl)piperidin-4-ylamine with 2,4-dimethylbenzoic acid. MS: 401.4 (MH+).

出典と根拠

ORDレコード
ord-2a254210d142474db34b99cb74026254
出典データセット
uspto-grants-2010_08
特許番号
US07772253B2

関連ノート

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