Potassium Hydroxide → 2-(1-Methylethyl)-3-quinolinol

HRID 502626ノート

反応式

HRID 502626 の反応式
[CH:1]([C:4]1[C:13]([O:14]S(C2C=CC(C)=CC=2)(=O)=O)=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=1)([CH3:3])[CH3:2].[OH-].[K+].O1CCOCC1>O>[CH:1]([C:4]1[C:13]([OH:14])=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=1)([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 14797Potassium HydroxideHCID 312751,4-DioxaneHCID 86611057Toluene-4-sulfonic acid 2-isopropyl-quinolin-3-yl ester

生成物 1

HCID 684606892-(1-Methylethyl)-3-quinolinol収率 99.8%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of toluene-4-sulfonic acid 2-isopropyl-quinolin-3-yl ester (1.31 g, 3.8 mmol), 0.64 g (11.4 mmol) of KOH in 10 mL of water, and 50 mL of p-dioxane was heated to refluxe for 1.5 hours until completion. The p-dioxane was removed under reduced pressure and the residue was diluted with water and acidified with 1N HCl to pH=6. The aqueous solution was extracted with ethyl acetate and the combined organic layers were washed with brine, dried (MgSO4) and concentrated under reduced pressure to afford quantitatively 0.71 g of 2-isopropyl-quinolin-3-ol

後処理

  1. temperaturewas heated
  2. customThe p-dioxane was removed under reduced pressure
  3. additionthe residue was diluted with water
  4. extractionThe aqueous solution was extracted with ethyl acetate
  5. washthe combined organic layers were washed with brine
  6. dry with materialdried (MgSO4)
  7. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-9b92362140dd45df8c9f8b860560080f
出典データセット
uspto-grants-2010_08
特許番号
US07776872B2

反応ノート

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