Benzene → 4-Chloro-5-phenylfuro[2,3-d]pyrimidine
反応式
C1(C2C(=O)[C:11]34[CH2:18][CH2:17][O:16][C:12]3=[N:13][CH:14]=[N:15][C:10]4=CC=2)C=CC=CC=1.P(Cl)(Cl)([Cl:23])=O.[CH:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[Cl:23][C:10]1[C:11]2[C:18]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=[CH:17][O:16][C:12]=2[N:13]=[CH:14][N:15]=1参加物
4
実験手順
Into a 100 mL round bottom flask was placed 5-phenylfuro[2,3-d]benzopyrimidin-4 (3H)-one (1.12 g, 5.3 mmol) and benzene (75 mL). The flask was equipped with a stir bar, reflux condenser, and Dean-Stark trap, and the reaction was allowed to reflux with stirring for 1 hour azeotropically removing the water formed. The reaction was cooled to room temperature. Phosphorus oxychloride was added (2.43 g, 15.9 mmol) dropwise, the flask equipped with a reflux condenser and the reaction was heated at reflux for 20 hours with stirring.