Hydrochloric Acid → 4-(Cyclopropylmethyl)-piperidine-4-carbonitrile hydrochloride
反応式
[C:1]([C:3]1([CH2:16][CH:17]2[CH2:19][CH2:18]2)[CH2:8][CH2:7][N:6](C(OC(C)(C)C)=O)[CH2:5][CH2:4]1)#[N:2].[ClH:20]>O1CCOCC1>[ClH:20].[CH:17]1([CH2:16][C:3]2([C:1]#[N:2])[CH2:4][CH2:5][NH:6][CH2:7][CH2:8]2)[CH2:19][CH2:18]1参加物
4
実験手順
A sample of tert-butyl 4-cyano-4-(cyclopropylmethyl)piperidine-1-carboxylate (I-2, 3.6 g, 13.6 mmol) was treated with HCl (40 mL of a 4.0 M solution in dioxane) and stirred at room temperature for 2 h before being concentrated under reduced pressure to afford 4-(cyclopropylmethyl)-piperidine-4-carbonitrile hydrochloride (I-3, M+H+=165.1) which was used without further purification.
後処理
- concentrationbefore being concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-8a47bd4fc14546ac99740ff21c19e1db
- 出典データセット
- uspto-grants-2010_08
- 特許番号
- US07776886B2
反応ノート
読み込み中…