HCID 68469062、化合物 → HCID 68470026、化合物
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:9]([CH3:24])[C:10]([C:13]([CH3:23])([CH3:22])[CH:14]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[OH:15])=[N:11][N:12]=1>[O-2].[O-2].[Mn+4].C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:9]([CH3:24])[C:10]([C:13]([CH3:22])([CH3:23])[C:14]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[O:15])=[N:11][N:12]=1参加物
4
実験手順
Manganese dioxide (955 mg) was gradually added to a methylene chloride (4.8 ml) solution of 2-[5-(2-chlorophenyl)-4-methyl-4H-1,2,4-triazol-3-yl]-2-methyl-1-phenylpropan-1-ol (191 mg) under ice cooling. The reaction mixture was stirred at room temperature for 3 hours and then manganese dioxide (955 mg) was added thereto, followed by stirring at room temperature for another 18.5 hours. Then, the mixture was subjected to filtration through celite. The filtrate was subjected to evaporation under reduced pressure and then purified by silica gel column chromatography (chloroform:methanol=50:1) to obtain 2-[5-(2-chlorophenyl)-4-methyl-4H-1,2,4-triazol-3-yl]-2-methyl-1-phenylpropan-1-one (140 mg).