Acetic Acid → 1H-Indazole-5-carboxylic acid
反応式
[NH:1]1[C:9]2[C:4](=[CH:5]C(C#N)=[CH:7][CH:8]=2)[CH:3]=[N:2]1.[C:12]([OH:15])(=[O:14])[CH3:13].S(=O)(=O)(O)O>O>[NH:1]1[C:9]2[C:4](=[CH:5][C:13]([C:12]([OH:15])=[O:14])=[CH:7][CH:8]=2)[CH:3]=[N:2]1参加物
5
反応条件
- 温度
- 110 °C
実験手順
To 867 mg of 1H-5-indazolecarbonitrile used in Production Example I-14-a were added 8 ml of glacial acetic acid, 2.5 ml of water and 2 ml of concentrated sulfuric acid, and the mixture was stirred at 110° C. for 10 hours. After standing to cool, the mixture was added with 50 ml of water, and the resulting crystals were collected by filtration and dried in vacuo, to give 911 mg of the title compound as white crystals.
後処理
- temperatureto cool
- filtrationthe resulting crystals were collected by filtration
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-bc204de5d52c48139819620d59ac1096
- 出典データセット
- uspto-grants-2010_08
- 特許番号
- US07776890B2
反応ノート
読み込み中…