3-(3-fluorophenyl)-6-nitro-1H-indazole → 3-(3-Fluorophenyl)-1H-6-indazolamine

HRID 503130ノート

反応式

HRID 503130 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:16]3[C:11](=[CH:12][C:13]([N+:17]([O-])=O)=[CH:14][CH:15]=3)[NH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1>CO.C(OCC)(=O)C.[OH-].[Pd+2].[OH-].[C]>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:16]3[C:11](=[CH:12][C:13]([NH2:17])=[CH:14][CH:15]=3)[NH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 1

HCID 222608953-(3-fluorophenyl)-6-nitro-1H-indazole

生成物 1

HCID 222606883-(3-Fluorophenyl)-1H-6-indazolamine収率 53.6%

試薬・触媒・溶媒 3

HCID 178502593HCID 178502593、化合物触媒HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒2 回

実験手順

To a solution of 300 mg of 3-(3-fluorophenyl)-6-nitro-1H-indazole in 5 ml methanol and 2.5 ml ethyl acetate was added 60 mg of 20% palladium hydroxide-carbon (water content: 50%), and the mixture was subjected to hydrogenation at room temperature at normal pressure for 7.5 hours. After adding 2.5 ml of ethyl acetate to the reaction mixture, the catalyst was filtered off through Celite. The solvent was evaporated, and the crude product was suspended in ethyl acetate-diisopropyl ether, to give 142 mg of the title compound as white crystals.

後処理

  1. filtrationthe catalyst was filtered off through Celite
  2. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-5592c15a21aa48098fab608da03f043e
出典データセット
uspto-grants-2010_08
特許番号
US07776890B2

反応ノート

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