Water → 3-(3-Fluoro-phenyl)-6-methoxy-1H-indazole-5-carboxylic Acid

HRID 503158ノート

反応式

HRID 503158 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:16]3[C:11](=[CH:12][C:13]([O:19][CH3:20])=[C:14]([C:17]#N)[CH:15]=3)[NH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.[OH2:21].S(=O)(=O)(O)[OH:23]>C(O)(=O)C>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:16]3[C:11](=[CH:12][C:13]([O:19][CH3:20])=[C:14]([C:17]([OH:23])=[O:21])[CH:15]=3)[NH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 962Water2 回HCID 1118Sulfuric AcidHCID 222607803-(3-Fluoro-phenyl)-6-methoxy-1H-indazole-5-carbonitrile

生成物 1

HCID 222609563-(3-Fluoro-phenyl)-6-methoxy-1H-indazole-5-carboxylic Acid

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
110 °C

実験手順

A total of 172 mg of 3-(3-fluoro-phenyl)-6-methoxy-1H-indazole-5-carbonitrile obtained in Production Example II-1-d was dissolved in 2 ml of acetic acid, 0.7 ml of water and 0.5 ml of sulfuric acid, followed by stirring at 110° C. for 18 hours. After cooling to room temperature, water was added to the reaction mixture. The resulting crystals were washed with water, to give 159 mg of the title compound as light pink crystals.

後処理

  1. temperatureAfter cooling to room temperature
  2. washThe resulting crystals were washed with water

出典と根拠

ORDレコード
ord-c4f5ede5238741fd85045d91540c0195
出典データセット
uspto-grants-2010_08
特許番号
US07776890B2

反応ノート

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