Acetic Acid → 3-(3-fluorophenyl)-7-methoxy-1H-indazole-5-carboxylic acid

HRID 503171ノート

反応式

HRID 503171 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:16]3[C:11](=[C:12]([O:19][CH3:20])[CH:13]=C(C#N)[CH:15]=3)[NH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.[C:21]([OH:24])(=[O:23])[CH3:22].S(=O)(=O)(O)O>O>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:16]3[C:11](=[C:12]([O:19][CH3:20])[CH:13]=[C:22]([C:21]([OH:24])=[O:23])[CH:15]=3)[NH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 176Acetic AcidHCID 1118Sulfuric AcidHCID 222608863-(3-fluorophenyl)-7-methoxy-1H-indazole-5-carbonitrile

生成物 1

HCID 222607673-(3-fluorophenyl)-7-methoxy-1H-indazole-5-carboxylic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

反応条件

温度
100 °C

実験手順

To 450 mg of 3-(3-fluorophenyl)-7-methoxy-1H-indazole-5-carbonitrile were sequentially added 6 ml of glacial acetic acid, 2 ml of water and 2 ml of concentrated sulfuric acid, followed by stirring at 100° C. for one day. After standing to cool, water was added to the reaction mixture and the resulting crystals were collected by filtration. The crystals were sequentially washed with isopropanol and diethyl ether, to give 428 mg of the title compound as colorless crystals.

後処理

  1. temperatureto cool
  2. filtrationthe resulting crystals were collected by filtration
  3. washThe crystals were sequentially washed with isopropanol and diethyl ether

出典と根拠

ORDレコード
ord-597946e8d3904aa9b943d464b0a8db8b
出典データセット
uspto-grants-2010_08
特許番号
US07776890B2

反応ノート

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