Diphenyl Ether → Methoxy-1H-[1,5]naphthyridin-4-one

HRID 503508ノート

反応式

HRID 503508 の反応式
CO[C:3]1[CH:4]=[C:5]([NH:9][CH:10]=[C:11]2[C:16](=[O:17])OC(C)(C)OC2=O)[CH:6]=[N:7][CH:8]=1.[C:21]1([O:27]C2C=CC=CC=2)C=CC=CC=1>CCCCCC>[CH3:21][O:27][N:9]1[C:5]2[C:6](=[N:7][CH:8]=[CH:3][CH:4]=2)[C:16](=[O:17])[CH:11]=[CH:10]1

参加物

4

反応物 2

HCID 7583Diphenyl EtherHCID 673177565-[(5-Methoxy-pyridin-3-ylamino)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione

生成物 1

HCID 86628663Methoxy-1H-[1,5]naphthyridin-4-one

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒2 回

反応条件

温度
245 °C

実験手順

A two-necked RBF equipped with an air condenser was charged with 5-[(5-Methoxy-pyridin-3-ylamino)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione (18 g) and diphenyl ether (180 mL). The reaction mixture was heated at 240-250° C. for 5 min under N2 atmosphere after which it was cooled to RT, diluted with hexane and filtered to obtain a dark solid. The crude product was refluxed in hexane for 30 min and filtered to obtain product as a brown solid.

後処理

  1. customA two-necked RBF equipped with an air condenser
  2. temperaturewas cooled to RT
  3. filtrationfiltered
  4. customto obtain a dark solid
  5. filtrationfiltered
  6. customto obtain product as a brown solid

出典と根拠

ORDレコード
ord-99d16993261140f5bda07cb5d9d05af5
出典データセット
uspto-grants-2010_08
特許番号
US07776857B2

反応ノート

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