1,3-Dioxane-4,6-dione, 5-[[(6-methoxy-3-pyridinyl)amino]methylene]-2,2-dimethyl- → 6-Methoxy-1,5-naphthyridin-4-ol

HRID 503511ノート

反応式

HRID 503511 の反応式
[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([NH:9][CH:10]=[C:11]2[C:16](=[O:17])OC(C)(C)OC2=O)=[CH:5][CH:4]=1>C1(OC2C=CC=CC=2)C=CC=CC=1.CCCCCC>[CH3:1][O:2][C:3]1[N:8]=[C:7]2[C:6](=[CH:5][CH:4]=1)[NH:9][CH:10]=[CH:11][C:16]2=[O:17]

参加物

4

反応物 1

HCID 42557991,3-Dioxane-4,6-dione, 5-[[(6-methoxy-3-pyridinyl)amino]methylene]-2,2-dimethyl-

生成物 1

HCID 113788076-Methoxy-1,5-naphthyridin-4-ol

試薬・触媒・溶媒 2

HCID 7583Diphenyl Ether溶媒HCID 8058Hexane溶媒

反応条件

温度
250 °C

実験手順

A suspension of 5-((6-methoxypyridin-3-ylamino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione (51.3 g, 0.185 mol) in diphenylether (1275 mL) was heated to 250° C. under nitrogen atmosphere for 20 min. The reaction mixture was cooled to RT and diluted with hexane. The gummy solid was then triturated with hexane to obtain 6-methoxy-1,5-naphthyridin-4(1H)-one as a pale brown color solid.

後処理

  1. temperatureThe reaction mixture was cooled to RT
  2. customThe gummy solid was then triturated with hexane

出典と根拠

ORDレコード
ord-479d52aedbb74aee93e336f96ca89b49
出典データセット
uspto-grants-2010_08
特許番号
US07776857B2

反応ノート

読み込み中…