1-Hydroxybenzotriazole → (R)-methyl 1-(2-(((9H-fluoren-9-yl)methoxy)carbonyl)acetyl)-4,4-difluoropyrrolidine-2-carboxylate

反応式

[C:1](NCC(O)=O)([O:3][CH2:4][CH:5]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]2[C:6]1=[CH:7][CH:8]=[CH:9][CH:10]=2)=[O:2].N1(O)C2C=CC=CC=2N=N1.[OH:33][C:34]([C:36](F)(F)F)=O.[CH3:40][O:41][C:42]([C@@H:44]1[CH2:48][C:47]([F:50])([F:49])[CH2:46][NH:45]1)=[O:43].F[P-](F)(F)(F)(F)F.N1(O[P+](N(C)C)(N(C)C)N(C)C)C2C=CC=CC=2N=N1>C(Cl)Cl.CN(C=O)C>[CH:16]1[C:17]2[CH:5]([CH2:4][O:3][C:1]([CH2:36][C:34]([N:45]3[CH2:46][C:47]([F:50])([F:49])[CH2:48][C@@H:44]3[C:42]([O:41][CH3:40])=[O:43])=[O:33])=[O:2])[C:6]3[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=3)[C:12]=2[CH:13]=[CH:14][CH:15]=1