Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) → 2-Iodo-5-[(2-(3-fluorophenyl)butanoyl)amino]benzamide

HRID 503699

反応式

HRID 503699 の反応式
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([I:11])=[C:6]([CH:10]=1)[C:7]([NH2:9])=[O:8].[F:12][C:13]1[CH:14]=[C:15]([CH:19]([CH2:23][CH3:24])[C:20](O)=[O:21])[CH:16]=[CH:17][CH:18]=1.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>>[I:11][C:5]1[CH:4]=[CH:3][C:2]([NH:1][C:20](=[O:21])[CH:19]([C:15]2[CH:16]=[CH:17][CH:18]=[C:13]([F:12])[CH:14]=2)[CH2:23][CH3:24])=[CH:10][C:6]=1[C:7]([NH2:9])=[O:8]

参加物

4

反応物 3

HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 155476225-Amino-2-iodobenzamideHCID 22275741HCID 22275741、化合物

生成物 1

HCID 686885472-Iodo-5-[(2-(3-fluorophenyl)butanoyl)amino]benzamide

実験手順

2-Iodo-5-[(2-(3-fluorophenyl)butanoyl)amino]benzamide is prepared from 5-amino-2-iodobenzamide and 2-(3-fluorophenyl)butanoic acid under standard amide coupling conditions with HATU.

出典と根拠

ORDレコード
ord-2cec9beeb39a49f08c4cc812c38f64ac
出典データセット
uspto-grants-2010_08
特許番号
US07776922B2

関連ノート

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