1-Benzothiophene-2-Sulfonamide → 3-{4-[2-({[(1-BENZOTHIEN-2-YLSULFONYL)AMINO]CARBONYL}AMINO)ETHYL]PHENYL}-2-ETHYL-5,7-DIMETHYL-3H-IMIDAZO[4,5-b]PYRIDINE

HRID 50431

反応式

HRID 50431 の反応式
C1(C2C=CC=CC=2)C=C[C:4]([S:7]([NH:10][C:11]([NH:13][CH2:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([N:22]3[C:26]4=[N:27][C:28]([CH3:32])=[CH:29][C:30]([CH3:31])=[C:25]4[N:24]=[C:23]3[CH2:33][CH3:34])=[CH:18][CH:17]=2)=[O:12])(=[O:9])=[O:8])=[CH:3]C=1.[S:41]1[C:45]2[CH:46]=[CH:47][CH:48]=[CH:49][C:44]=2C=C1S(N)(=O)=O>>[S:41]1[C:45]2[CH:46]=[CH:47][CH:48]=[CH:49][C:44]=2[CH:3]=[C:4]1[S:7]([NH:10][C:11]([NH:13][CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][C:19]([N:22]2[C:26]3=[N:27][C:28]([CH3:32])=[CH:29][C:30]([CH3:31])=[C:25]3[N:24]=[C:23]2[CH2:33][CH3:34])=[CH:18][CH:17]=1)=[O:12])(=[O:9])=[O:8]

参加物

3

反応物 2

HCID 106800961-Benzothiophene-2-SulfonamideHCID 218756193-{4-[2-({[(4-biphenylsulfonyl)amino]carbonyl}amino)ethyl]phenyl}-2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine

生成物 1

HCID 218760883-{4-[2-({[(1-BENZOTHIEN-2-YLSULFONYL)AMINO]CARBONYL}AMINO)ETHYL]PHENYL}-2-ETHYL-5,7-DIMETHYL-3H-IMIDAZO[4,5-b]PYRIDINE

実験手順

The title compound was prepared according to the procedure described in step 2 of Example 18 from phenyl 2-[4-(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl]ethylcarbamate (step 1 of Example 18) and 1-benzothiophene-2-sulfonamide (Chern, J.; Leu, Y.; et al. J. Med. Chem., 1997, 40, 2276.; Graham, S. L.; Shepard, K. L.; et al. J. Med. Chem., 1989, 32, 2548).

出典と根拠

ORDレコード
ord-9d50be13a3e940608273703fb17d0e18
出典データセット
uspto-grants-2004_03
特許番号
US06710054B2

関連ノート

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