3-Benzoylpropionic acid → N-{[(2-{4-[5,7-dimethyl-2-(3-oxo-3-phenylpropyl)-3H-imidazo[4,5-B]pyridin-3-yl]phenyl}ethyl)amino]carbonyl}-4-methylbenzenesulfonamide

HRID 50444

反応式

HRID 50444 の反応式
[NH2:1][C:2]1[C:3]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([CH2:17][CH2:18][NH:19][C:20]([NH:22][S:23]([C:26]3[CH:31]=[CH:30][C:29]([CH3:32])=[CH:28][CH:27]=3)(=[O:25])=[O:24])=[O:21])=[CH:13][CH:12]=2)=[N:4][C:5]([CH3:9])=[CH:6][C:7]=1[CH3:8].[C:33]([CH2:41][CH2:42][C:43](O)=O)(=[O:40])[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1>>[CH3:9][C:5]1[N:4]=[C:3]2[N:10]([C:11]3[CH:16]=[CH:15][C:14]([CH2:17][CH2:18][NH:19][C:20]([NH:22][S:23]([C:26]4[CH:27]=[CH:28][C:29]([CH3:32])=[CH:30][CH:31]=4)(=[O:25])=[O:24])=[O:21])=[CH:13][CH:12]=3)[C:43]([CH2:42][CH2:41][C:33](=[O:40])[C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)=[N:1][C:2]2=[C:7]([CH3:8])[CH:6]=1

参加物

3

反応物 2

HCID 728713-Benzoylpropionic acidHCID 218756203-Amino-4,6-dimethyl-2-(4-{2-[({[(4-methylphenyl)sulfonyl]amino}carbonyl)amino]ethyl}anilino)pyridine

生成物 1

HCID 21875545N-{[(2-{4-[5,7-dimethyl-2-(3-oxo-3-phenylpropyl)-3H-imidazo[4,5-B]pyridin-3-yl]phenyl}ethyl)amino]carbonyl}-4-methylbenzenesulfonamide

実験手順

The title compound was prepared according to the procedure described in Example 241 from N-{[(2-{4-[(3-amino-4,6-dimethyl-2-pyridinyl)amino]phenyl}ethyl)amino]carbonyl}-4-methylbenzenesulfonamide (step 4 of Example 162) and 3-benzoylpropionic acid.

出典と根拠

ORDレコード
ord-ec724e03576642ca9d8d97ceaaf5a08b
出典データセット
uspto-grants-2004_03
特許番号
US06710054B2

関連ノート

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