2,4-Dichloro-5-nitrobenzotrifluoride → (1r)-2-{4-[6-Chloro-2-ethyl-5-(trifluoromethyl)-1h-benzimidazol-1-yl]phenyl}-1-methylethyl (4-methylphenyl)sulfonylcarbamate

HRID 50448ノート

反応式

HRID 50448 の反応式
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[C:5]([N+:9]([O-])=O)=[CH:4][C:3]=1[C:12]([F:15])([F:14])[F:13].[CH3:16][C:17]1[CH:22]=[CH:21][C:20]([S:23]([NH:26][C:27](=[O:52])[O:28][C@H:29]([CH3:51])[CH2:30][C:31]2[CH:36]=[CH:35][C:34]([N:37]3C4C=CC(C(=O)C)=CC=4N=[C:38]3[CH2:49][CH3:50])=[CH:33][CH:32]=2)(=[O:25])=[O:24])=[CH:19][CH:18]=1>>[CH3:16][C:17]1[CH:22]=[CH:21][C:20]([S:23]([NH:26][C:27](=[O:52])[O:28][C@H:29]([CH3:51])[CH2:30][C:31]2[CH:32]=[CH:33][C:34]([N:37]3[C:6]4[CH:7]=[C:2]([Cl:1])[C:3]([C:12]([F:15])([F:14])[F:13])=[CH:4][C:5]=4[N:9]=[C:38]3[CH2:49][CH3:50])=[CH:35][CH:36]=2)(=[O:25])=[O:24])=[CH:19][CH:18]=1

参加物

3

反応物 2

HCID 6211792,4-Dichloro-5-nitrobenzotrifluorideHCID 86759399HCID 86759399、化合物

生成物 1

HCID 91091514(1r)-2-{4-[6-Chloro-2-ethyl-5-(trifluoromethyl)-1h-benzimidazol-1-yl]phenyl}-1-methylethyl (4-methylphenyl)sulfonylcarbamate

実験手順

The title compound was prepared according to the procedure described in step 1 of Example 162 from 2,4-dichloro-5-nitrobenzotrifluoride and (2R)-1-(4-aminophenyl)-2-propanol (step 2 of Example 249).

出典と根拠

ORDレコード
ord-b8fda62f08b94d5992ff3866f93cf372
出典データセット
uspto-grants-2004_03
特許番号
US06710054B2

反応ノート

読み込み中…