Lithium hydroxide, monohydrate → Lithium 2-amino-6-chloronicotinate

HRID 505068ノート

反応式

HRID 505068 の反応式
O[Li:2].O.[NH2:4][C:5]1[N:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:6]=1[C:7]([O:9]C)=[O:8]>O.CO>[NH2:4][C:5]1[N:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:6]=1[C:7]([O-:9])=[O:8].[Li+:2]

参加物

5

反応物 2

HCID 168937Lithium hydroxide, monohydrateHCID 57415887Methyl 2-amino-6-chloronicotinate

生成物 1

HCID 59772570Lithium 2-amino-6-chloronicotinate収率 114.3%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

反応条件

温度
70 °C

実験手順

A solution of LiOH.H2O (1.38 g, 33 mmol) in water (33 mL) was added in one portion to a suspension of methyl 2-amino-6-chloronicotinate (6.08 g, 27 mmol) in MeOH (110 mL). The reaction mixture was stirred at 70° C. for 24 hours, and gradually became homogeneous. The solvents were removed under reduced pressure, and after the resulting white solid was dried under vacuum (<1 mmHg) to constant weight, 5.51 g (95%) of lithium 2-amino-6-chloronicotinate was obtained.

後処理

  1. customThe solvents were removed under reduced pressure
  2. customafter the resulting white solid was dried under vacuum (<1 mmHg) to constant weight

出典と根拠

ORDレコード
ord-abc11101d7ea4bea821c01a30c9631ae
出典データセット
uspto-grants-2010_08
特許番号
US07781437B2

反応ノート

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