(6-chloro-1H-indol-3-yl)-[4-(2,6-dimethoxy-phenyl)-piperidin-1-yl]-methanone → [6-Chloro-1-(6-chloro-pyridin-3-ylmethyl)-1H-indol-3-yl]-[4-(2,6-dimethoxy-phenyl)-piperidin-1-yl]-methanone

HRID 505092ノート

反応式

HRID 505092 の反応式
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]([N:13]3[CH2:18][CH2:17][CH:16]([C:19]4[C:24]([O:25][CH3:26])=[CH:23][CH:22]=[CH:21][C:20]=4[O:27][CH3:28])[CH2:15][CH2:14]3)=[O:12])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[Cl:29][C:30]1[N:35]=[CH:34][C:33]([CH2:36]OS(C)(=O)=O)=[CH:32][CH:31]=1>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]([N:13]3[CH2:14][CH2:15][CH:16]([C:19]4[C:24]([O:25][CH3:26])=[CH:23][CH:22]=[CH:21][C:20]=4[O:27][CH3:28])[CH2:17][CH2:18]3)=[O:12])=[CH:7][N:8]2[CH2:36][C:33]2[CH:34]=[N:35][C:30]([Cl:29])=[CH:31][CH:32]=2)=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 16062188(6-chloro-1H-indol-3-yl)-[4-(2,6-dimethoxy-phenyl)-piperidin-1-yl]-methanoneHCID 23020401(6-Chloropyridin-3-yl)methyl methanesulphonate

生成物 1

HCID 16062308[6-Chloro-1-(6-chloro-pyridin-3-ylmethyl)-1H-indol-3-yl]-[4-(2,6-dimethoxy-phenyl)-piperidin-1-yl]-methanone

実験手順

Following general procedure II, the alkylation of (6-chloro-1H-indol-3-yl)-[4-(2,6-dimethoxy-phenyl)-piperidin-1-yl]-methanone (preparation described herein), with methanesulfonic acid 6-chloro-pyridin-3-ylmethyl ester (described in Journal of Organic Chemistry (1999), 64(23), 8576-8581) gave the title compound.

出典と根拠

ORDレコード
ord-a58eda1dc8294b3aa54970d77eaf512a
出典データセット
uspto-grants-2010_08
特許番号
US07781436B2

反応ノート

読み込み中…