1-(2-Fluorophenyl)piperazine → (6-Chloro-1H-indol-3-yl)[4-(2-fluorophenyl)piperazin-1-yl]methanone

反応式

[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1.[Cl:14][C:15]1[CH:23]=[C:22]2[C:18]([C:19]([C:24](O)=[O:25])=[CH:20][NH:21]2)=[CH:17][CH:16]=1>>[Cl:14][C:15]1[CH:23]=[C:22]2[C:18]([C:19]([C:24]([N:11]3[CH2:12][CH2:13][N:8]([C:3]4[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=4[F:1])[CH2:9][CH2:10]3)=[O:25])=[CH:20][NH:21]2)=[CH:17][CH:16]=1

参加物

反応物 2

HCID 705291-(2-Fluorophenyl)piperazine

HCID 184532356-chloro-1H-indole-3-carboxylic acid

生成物 1

HCID 16061731(6-Chloro-1H-indol-3-yl)[4-(2-fluorophenyl)piperazin-1-yl]methanone

実験手順

Following general procedure I, the coupling of (commercially available) 1-(2-fluoro-phenyl)-piperazine (described herein) with 6-chloro-1H-indole-3-carboxylic acid gave the title compound.

出典と根拠

ORDレコード: ord-8d549e7cb1484da586544d10e48ed423
出典データセット: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07781436B2

反応ノート

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