Triacetoxyperiodinane → HCID 178501146、化合物

HRID 505270ノート

反応式

HRID 505270 の反応式
[OH:1][CH2:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9]([O:11][CH3:12])=[O:10])[CH2:5][CH2:4]1.CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O>C(Cl)Cl.CCOC(C)=O>[CH:2]([C@H:3]1[CH2:4][CH2:5][C@H:6]([C:9]([O:11][CH3:12])=[O:10])[CH2:7][CH2:8]1)=[O:1]

参加物

5

反応物 2

HCID 159087TriacetoxyperiodinaneHCID 178501147HCID 178501147、化合物

生成物 1

HCID 178501146HCID 178501146、化合物

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a flask containing methyl trans-4-(hydroxymethyl)cyclohexanecarboxylate (100 mg, 0.581 mmol) in CH2Cl2 (5.8 mL) at 0° C., was added Dess-Martin periodinane (493 mg, 1.16 mmol). The reaction was allowed to warm to room temperature over an hour and then was diluted with EtOAc (60 mL), washed with saturated K2CO3 solution (3×40 mL) and brine (40 mL). The organic layer was dried over Na2SO4, filtered, and concentrated. Purification of the residue by flash chromatography on silica gel (0 to 25% EtOAc/hexanes) afforded methyl trans-4-formylcyclohexanecarboxylate. Rf=0.87 (25% EtOAc/hexanes). 1H NMR (CDCl3, 500 MHz) δ 9.63 (s, 1H), 3.67 (s, 3H), 2.51-2.05 (m, 6H), 1.63-1.26 (m, 4H).

後処理

  1. washwashed with saturated K2CO3 solution (3×40 mL) and brine (40 mL)
  2. dry with materialThe organic layer was dried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customPurification of the residue by flash chromatography on silica gel (0 to 25% EtOAc/hexanes)

出典と根拠

ORDレコード
ord-c9c564c38abd463894deb01d5fc025bf
出典データセット
uspto-grants-2010_08
特許番号
US07781426B2

反応ノート

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