4-Ethynyl-N,N-dimethylaniline → HCID 15603447、化合物

反応式

[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH3:11])[CH3:10])=[CH:5][CH:4]=1)#[CH:2].[CH3:12][O:13][C:14]1[CH:15]=[C:16]([N:24]=[N+:25]=[N-:26])[CH:17]=[C:18]([O:22][CH3:23])[C:19]=1[O:20][CH3:21]>>[CH3:12][O:13][C:14]1[CH:15]=[C:16]([N:24]2[C:1]([C:3]3[CH:8]=[CH:7][C:6]([N:9]([CH3:11])[CH3:10])=[CH:5][CH:4]=3)=[CH:2][N:26]=[N:25]2)[CH:17]=[C:18]([O:22][CH3:23])[C:19]=1[O:20][CH3:21]

参加物

反応物 2

HCID 51918844-Ethynyl-N,N-dimethylaniline

HCID 59430102HCID 59430102、化合物

生成物 1

HCID 15603447HCID 15603447、化合物

反応条件

温度: 80 °C

実験手順

To a scintillation vial was added (4-ethynyl phenyl)-dimethyl amine (660 5 mmol) and 3,4,5-trimethoxyphenyl azide (1.05 g.; 5 mmol) and the mixture was heated at 80° C. for 24 hours. The crude mixture was purified by column chromatography to give 1-(3,4,5-trimethoxy-phenyl)-5-[4-(N,N-dimethylamino)-phenyl]-1H-[1,2,3]triazole.

後処理

customThe crude mixture was purified by column chromatography

出典と根拠

ORDレコード: ord-d6342041c0d84c67adf62e84ad22a8f5
出典データセット: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07781462B2

反応ノート

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