3-(3-Pyridyl)-2-propyn-1-ol → 3-(3-Pyridinyl)-2-propynal
反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]#[C:8][CH2:9][OH:10])[CH:2]=1>C(Cl)Cl>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]#[C:8][CH:9]=[O:10])[CH:2]=1参加物
3
実験手順
A solution of 3-(3-pyridinyl)-2-propynol (500 mg, 3.75 mmol) in CH2Cl2 (5 mL) was treated with activated manganous dioxide (3.3 g, 34.5 mmol) at 25° C. After 12 h, the reaction mixture was filtered through celite, washed with CH2Cl2 (2×50 mL), concentrated in vacuo. Purification by flash chromatography afforded the title compound (100 mg, 20%) as yellow brown oil. MS 133 (M+H)+.
後処理
- filtrationthe reaction mixture was filtered through celite
- washwashed with CH2Cl2 (2×50 mL)
- concentrationconcentrated in vacuo
- customPurification by flash chromatography
出典と根拠
- ORDレコード
- ord-aee94fb66d904832999dbb007280ff5f
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06713455B2
反応ノート
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