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HRID 505759作成日：2026年10月26日

(-)-2-Butanol → (+/-)-(3SR,3aRS)-((R)-sec-butyl) 2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylate

https://huagongshe.com/reaction/505759

反応式

関与物質

役割名称HCID仕込み量
反応物(-)-2-ButanolHCID 84682—
反応物(+/-)(3SR,3aRS)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acidHCID 24983760—
生成物(+/-)-(3SR,3aRS)-((R)-sec-butyl) 2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylateHCID 6880024768%

反応手順

The title compound was prepared from (±)-(3SR,3aRS)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid, Example 15 and (R)-butan-2-ol according to Method E (yellow solid, 155 mg, 0.326 mmol, 68% yield). ES-HRMS m/z calc. for C28H31ClN3O2 (M+H) 476.2099, found 476.2100.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07781428B2
出典データセットuspto-grants-2010_08
ORD IDord-1804d183a7df4d24968994cfede87a89
出典メモuspto-grants-2010_08