2-Methylimidazole → 2-(2-Methyl-1H-imidazol-1-yl)ethan-1-amine

反応式

[CH3:1][C:2]1[NH:3][CH:4]=[CH:5][N:6]=1.Cl.Cl[CH2:9][CH2:10][NH2:11]>>[CH3:1][C:2]1[N:3]([CH2:9][CH2:10][NH2:11])[CH:4]=[CH:5][N:6]=1

参加物

反応物 2

HCID 127492-Methylimidazole

HCID 97937372-Chloroethylamine hydrochloride

生成物 1

HCID 31574802-(2-Methyl-1H-imidazol-1-yl)ethan-1-amine収率 47%

実験手順

2-(2-Methylimidazol-1-yl)ethylamine was prepared from 2-methylimidazole and 2-chloroethylamine hydrochloride using the method described in Step B of Example 1. This material was obtained as a light yellow oil in 47% yield. 1H NMR (300 MHz, CD3OD) δ 6.95 (br s, 1H), 6.82 (br s, 1H), 4.90 (bs, 2H), 3.90 (t, J=6.9 Hz, 2H), 2.93 (t, J=6.9 Hz, 2H), 2.35 (s, 3H); MS (APCI) m/z 126 [M+H]+.

後処理

customThis material was obtained as a light yellow oil in 47% yield

出典と根拠

ORDレコード: ord-ef143cb139f24853b6983daf34d09806
出典データセット: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07781430B2

反応ノート

読み込み中…