Hydrochloric Acid → Ethyl (2s)-2-[2'-(2-bromophenyl)thio-3'-(4-methoxyphenyl)propanoyl]amino-4-methylpentanoate

関与物質

役割	名称	HCID	仕込み量
反応物	Hydrochloric Acid	HCID 313	—
反応物	1-Hydroxybenzotriazole	HCID 75771	—
反応物	L-Leucine ethyl ester	HCID 75971	—
反応物	1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride	HCID 2723939	—
反応物	2-(2-Bromophenyl)thio-3-(4-methoxyphenyl)propanoic acid	HCID 22736619	—
溶媒	Dimethylformamide	HCID 6228	—
生成物	Ethyl (2s)-2-[2'-(2-bromophenyl)thio-3'-(4-methoxyphenyl)propanoyl]amino-4-methylpentanoate	HCID 91156048	—

反応手順

To a solution of 2-(2-bromophenyl)thio-3-(4-methoxyphenyl)propanoic acid (1.102 g) and L-leucine ethyl ester.HCl (704 mg) in DMF (10 mL), HOBt (551 mg) and EDC.HCl (690 mg) were added. The reaction mixture was stirred at r.t. overnight. The solvent was removed under reduced pressure. The residue was dissolved in EtOAc and washed with 1N HCl, 5% Na2CO3 aq. and brine. The organic layer was dried over Na2SO4 and concentrated to give the pure product as a pale yellow oil (1.561 g, quant.).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US06713477B1
出典データセット	uspto-grants-2004_03
ORD ID	ord-b6ea4dc3999243a4923133973afb1594
出典メモ	uspto-grants-2004_03