1-Iodoethyl cyclohexyl carbonate → 1-(Cyclohexyloxycarbonyloxy)ethyl (1R, 5S, 6S)-2-(2-oxo-4-pyrrolidinylthio)-6-[(1R)-1-hydroxyethyl]-1-methyl-1-carbapen-2-em-3-carboxylate
反応式
[O:1]=[C:2]1[CH2:6][CH:5]([S:7][C:8]2[CH:9]([CH3:22])[C@@H:10]3[CH:17]([C@H:18]([OH:20])[CH3:19])[C:16](=[O:21])[N:11]3[C:12]=2[C:13]([O-:15])=[O:14])[CH2:4][NH:3]1.[Na+].[CH:24]1([O:30][C:31]([O:33][CH:34](I)[CH3:35])=[O:32])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1>>[O:1]=[C:2]1[CH2:6][CH:5]([S:7][C:8]2[C@H:9]([CH3:22])[C@@H:10]3[C@@H:17]([C@H:18]([OH:20])[CH3:19])[C:16](=[O:21])[N:11]3[C:12]=2[C:13]([O:15][CH:34]([O:33][C:31]([O:30][CH:24]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)=[O:32])[CH3:35])=[O:14])[CH2:4][NH:3]1参加物
3
反応物 2
生成物 1
実験手順
Following a procedure similar to that described in Example 39, but using 54 mg of sodium 2-(2-oxo-4-pyrrolidinylthio)-6-[(1R)-1-hydroxyethyl]-1-methyl-1-carbapen-2-em-3-carboxylate obtained by a similar procedure to that described in Example 36 and 50 μl of 1-(cyclohexyloxycarbonyloxy)ethyl iodide, 62 mg of the title compound were obtained as a colorless powder.