Potassium Hydroxide → 2,5-Dimethoxy acridine-9-carboxylic acid
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:19]2[C:14](=[CH:15][C:16]([O:20][CH3:21])=[CH:17][CH:18]=2)[C:12](=O)[C:10]1=[O:11].[OH-:22].[K+]>O>[CH3:21][O:20][C:16]1[CH:17]=[CH:18][C:19]2[C:14](=[C:12]([C:10]([OH:22])=[O:11])[C:5]3[C:4]([N:9]=2)=[C:3]([O:2][CH3:1])[CH:8]=[CH:7][CH:6]=3)[CH:15]=1参加物
4
実験手順
The crude isatin derivative from step (a) was refluxed in 60 mL of 10% potassium hydroxide in water for 4 hours. The reaction was then cooled to room temperature and filtered. The filtrate was acidified with a mixture of concentrated hydrochloric acid and ice until a dark precipitate separated out. The product was collected by filtration and dried under vacuum. Yield=0.32 g (10%).
後処理
- filtrationfiltered
- additionThe filtrate was acidified with a mixture of concentrated hydrochloric acid and ice until a dark precipitate
- customseparated out
- filtrationThe product was collected by filtration
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-2f5d74320229466cbc385bdf1138077e
- 出典データセット
- uspto-grants-2010_08
- 特許番号
- US07785904B2
反応ノート
読み込み中…