Cesium carbonate → [1-(4-Chloro-phenyl)-cyclobutyl]-{3-[4-(2-fluoro-phenyl)-piperazin-1-ylmethyl]-piperidin-1-yl}-methanone

関与物質

役割	名称	HCID	仕込み量
反応物	Cesium carbonate	HCID 10796	—
反応物	1-(2-Fluorophenyl)piperazine	HCID 70529	—
反応物	Methanesulfonic acid 1-[1-(4-chloro-phenyl)-cyclobutanecarbonyl]-piperidin-3-ylmethyl ester	HCID 12992442	—
生成物	[1-(4-Chloro-phenyl)-cyclobutyl]-{3-[4-(2-fluoro-phenyl)-piperazin-1-ylmethyl]-piperidin-1-yl}-methanone	HCID 12992446	46%

反応手順

Compound 8 was prepared using the method described in Example 3, starting with compound 2 (1.0 g, 2.60 mmol), 1-(2-fluorophenyl)piperazine (0.51 g, 2.86 mmol), and cesium carbonate (1.27 g, 3.90 mmol) to give 8 (0.56 g, 46%); C27H33ClFN3O, LRMS (m/z)=471 (MH+).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US06713479B2
出典データセット	uspto-grants-2004_03
ORD ID	ord-1aaa49faf76d44e2b39252fbc683a6bf
出典メモ	uspto-grants-2004_03