Benzaldehyde → 4-(2-(Diethylamino)-Ethoxy)-Benzaldehyde

HRID 506578

反応式

HRID 506578 の反応式
[OH-:1].[K+].Cl.Cl[CH2:5][CH2:6][N:7]([CH2:10][CH3:11])[CH2:8][CH3:9].[CH:12](=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C(O)C.O>[CH2:8]([N:7]([CH2:10][CH3:11])[CH2:6][CH2:5][O:1][C:16]1[CH:17]=[CH:18][C:13]([CH:12]=[O:19])=[CH:14][CH:15]=1)[CH3:9]

参加物

6

反応物 3

HCID 240BenzaldehydeHCID 133631-Chloro-2-(diethylamine)ethane hydrochlorideHCID 14797Potassium Hydroxide

生成物 1

HCID 4116744-(2-(Diethylamino)-Ethoxy)-Benzaldehyde

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

4.82 g potassium hydroxide were dissolved in 70 ml ethanol and treated with 8.46 g (2-Chloro-ethyl)-diethyl-amine hydrochloride. The mixture was stirred until everything was dissolved, then 5.0 g benzaldehyde were added and refluxed for 16 hrs. The mixture was diluted with water and extracted with ethyl acetate, and the organic phases washed several times with caustic soda. After drying and evaporation of the solvent the crude product was used without further purification.

後処理

  1. dissolutionwas dissolved
  2. temperaturerefluxed for 16 hrs
  3. extractionextracted with ethyl acetate
  4. washthe organic phases washed several times with caustic soda
  5. customAfter drying
  6. customevaporation of the solvent the crude product
  7. customwas used without further purification

出典と根拠

ORDレコード
ord-ccd87d0fe8414c9aaec4f9b0b134d9ca
出典データセット
uspto-grants-2010_08
特許番号
US07786113B2

関連ノート

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