2,5-Dimethylpyrrolidine, (2R,5R)- → 7-[3-((2r,5r)-2,5-Dimethyl-pyrrolidin-1-yl)-propoxy]-3,4-dihydro-2h-2,4a,5-triaza-fluoren-1-one

HRID 506747

反応式

HRID 506747 の反応式
[CH3:1][C@H:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:23]=[C:22]2[C:14]([N:15]3[C:20](=[CH:21]2)[C:19](=[O:24])[NH:18][CH2:17][CH2:16]3)=[N:13][CH:12]=1.[CH3:25][C@H]1N[C@H](C)CC1>>[CH3:1][C@@H:2]1[CH2:6][CH2:5][C@@H:4]([CH3:25])[N:3]1[CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:23]=[C:22]2[C:14]([N:15]3[C:20](=[CH:21]2)[C:19](=[O:24])[NH:18][CH2:17][CH2:16]3)=[N:13][CH:12]=1

参加物

3

反応物 2

HCID 6417672,5-Dimethylpyrrolidine, (2R,5R)-HCID 166790307-[3-((S)-2-Methyl-pyrrolidin-1-yl)-propoxy]-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one

生成物 1

HCID 166791237-[3-((2r,5r)-2,5-Dimethyl-pyrrolidin-1-yl)-propoxy]-3,4-dihydro-2h-2,4a,5-triaza-fluoren-1-one収率 19%

実験手順

The title compound was synthesized in analogy to example 2, from 7-(3-chloro-propoxy)-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one (example 85, intermediate) and (2R,5R)-(−)-trans-2,5-dimethylpyrrolidine (commercially available), to give the desired product as a colorless solid (19%).

出典と根拠

ORDレコード
ord-aa0b95eacb774d4eb011638974119b28
出典データセット
uspto-grants-2010_08
特許番号
US07786109B2

関連ノート

読み込み中…