Hydrochloric Acid → N-Methyl-N-(piperidin-4-yl)acetamide

HRID 506858ノート

反応式

HRID 506858 の反応式
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([C:16](=[O:18])[CH3:17])[CH3:15])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>CCOC(C)=O>[CH3:15][N:14]([CH:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)[C:16](=[O:18])[CH3:17]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 22061331tert-Butyl 4-[acetyl(methyl)amino]piperidine-1-carboxylate

生成物 1

HCID 21468403N-Methyl-N-(piperidin-4-yl)acetamide

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 4-(acetyl-methyl-amino)-piperidine-1-carboxylic acid tert-butyl ester (525 mg, 2.05 mmol) in AcOEt (5 ml) was added HCl 3N (4 ml). The reaction mixture was stirred at RT for 16 hrs. Solvent were removed under reduced pressure to gine the expected N-methyl-N-piperidin-4-yl-acetamide as its hydrochloride salt (395 mg, quant.).

後処理

  1. customSolvent were removed under reduced pressure

出典と根拠

ORDレコード
ord-0dd63d0f2e3c4e5e9183e378ca92637d
出典データセット
uspto-grants-2010_08
特許番号
US07786121B2

反応ノート

読み込み中…