Ammonium Hydroxide → 2-Chloro-4-quinolineacetamide

反応式

C[O:2][C:3](=O)[CH2:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([Cl:15])[CH:6]=1.[NH4+:17].[OH-]>>[Cl:15][C:7]1[CH:6]=[C:5]([CH2:4][C:3]([NH2:17])=[O:2])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=1

参加物

反応物 2

HCID 14923Ammonium Hydroxide

HCID 15185779158265-19-1

生成物 1

HCID 187708752-Chloro-4-quinolineacetamide

実験手順

2-(2-chloro-quinolin-4-yl)-acetic acid methyl ester (100 mg, 0.42 mmol) is suspended in 28% NH4OH (2.0 mL). The mixture is stirred at RT overnight. The solvent is evaporated to afford 2-(2-chloro-quinolin-4-yl)-acetamide as a solid.

後処理

customThe solvent is evaporated

出典と根拠

ORDレコード: ord-69d92b1271544b839037a197eeb33e93
出典データセット: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07786123B2

反応ノート

読み込み中…