1,3-Dibromo-5-fluorobenzene → 6-(3-Bromo-5-fluoro-phenyl)4,4-dicyclopropyl-1,4-dihydrobenzo-[d][1,3]oxazin-2-one

HRID 50707ノート

反応式

HRID 50707 の反応式
[CH:1]1([C:4]2([CH:18]3[CH2:20][CH2:19]3)[C:9]3[CH:10]=[C:11](B(O)O)[CH:12]=[CH:13][C:8]=3[NH:7][C:6](=[O:17])[O:5]2)[CH2:3][CH2:2]1.[Br:21][C:22]1[CH:27]=[C:26]([F:28])[CH:25]=[C:24](Br)[CH:23]=1>>[Br:21][C:22]1[CH:23]=[C:24]([C:11]2[CH:12]=[CH:13][C:8]3[NH:7][C:6](=[O:17])[O:5][C:4]([CH:18]4[CH2:20][CH2:19]4)([CH:1]4[CH2:3][CH2:2]4)[C:9]=3[CH:10]=2)[CH:25]=[C:26]([F:28])[CH:27]=1

参加物

3

反応物 2

HCID 1370031,3-Dibromo-5-fluorobenzeneHCID 23509592(4,4-dicyclopropyl-1,4-dihydro-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid

生成物 1

HCID 101579196-(3-Bromo-5-fluoro-phenyl)4,4-dicyclopropyl-1,4-dihydrobenzo-[d][1,3]oxazin-2-one

実験手順

Prepared according to Procedure B from (4,4-dicyclopropyl-1,4-dihydro-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid and 1,3-dibromo-5-fluorobenzene. A white solid: mp 228-229° C.; 1H-NMR (DMSO-d6) δ 10.3 (s, 1H), 7.76-7.72 (m, 2H), 7.65 (dd, 1H, J=8.32, 1.74 Hz), 7.60 (d, 1H, J=10.36 Hz), 7.51 (d, 1H, J=8.3 Hz), 6.93 (d, 1H, J=8.31 Hz), 1.63-1.54 (m, 2H), 0.58-0.41 (m, 6H), 0.30-0.28 (m, 2H); MS (APCI) m/z 402/404 ([M−H]−, 100%); Anal. Calc. For C20H17BrFNO2: C, 58.48; H, 4.17; N, 3.41. Found: C, 58.77; H, 4.23; N, 3.32.

後処理

  1. customPrepared

出典と根拠

ORDレコード
ord-10046bebaccb483e87af1b83c00e4b93
出典データセット
uspto-grants-2004_03
特許番号
US06713478B2

反応ノート

読み込み中…