Brofoxine → 6-(3,5Dichloro-phenyl)4,4-dimethyl-1,4-dihydrobenzo[d][1,3]-oxazin-2-one

関与物質

役割	名称	HCID	仕込み量
反応物	Brofoxine	HCID 30630	—
反応物	3,5-Dichlorophenylboronic acid	HCID 2734331	—
生成物	6-(3,5Dichloro-phenyl)4,4-dimethyl-1,4-dihydrobenzo[d][1,3]-oxazin-2-one	HCID 9927148	—

反応手順

Prepared from 6-bromo-4,4-dimethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one and 3,5-dichlorophenyl boronic acid according to Procedure A. A white solid: mp 245-246° C.; 1H-NMR (DMSO-d6) δ 10.4 (s, 1H), 7.77 (m, 2H), 7.67-7.64 (m, 2H), 7.56 (bs, 1H), 6.96 (d, 1H, J=7.98 Hz), 1.7 (s, 6H); MS (EI) m/z 321 ([M+H]+, 40%); Anal. Calc. For C16H13Cl2NO2: C, 59.32; H, 4.11; N, 4.32. Found: C, 59.13; H, 4.29, N, 4.17.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US06713478B2
出典データセット	uspto-grants-2004_03
ORD ID	ord-33e1dbf12d2f4bc0af16b418cf03793f
出典メモ	uspto-grants-2004_03