化工社化工社 化学情報印刷レポート · 研究参考用
Sodium hydride → 2-Phenoxymethyl-1-(4-trifluoromethylsulfanyl-benzyl)-1H-indole-5-carboxylic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 4-(Trifluoromethylthio)benzyl bromide | HCID 2777882 | — |
| 反応物 | 2-Phenoxymethyl-1H-indole-5-carboxylic acid methyl ester | HCID 59732213 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-Phenoxymethyl-1-(4-trifluoromethylsulfanyl-benzyl)-1H-indole-5-carboxylic acid methyl ester | HCID 68463737 | — |
反応手順
30 mg of 2-phenoxymethyl-1H-indole-5-carboxylic acid methyl ester were dissolved in 1 ml of THF and treated with 5 mg NaH (60%) at 0° C. for 15 min. 1.2 eq. of 1-bromomethyl-4-trifluoromethylsulfanyl-benzene were added and the reaction stirred for 1.5 h. The solvent was evaporated and the product extracted from methylenchloride/water. The product was purified by preparative HPLC. MS(ISP): 472.5 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07786128B2 |
| 出典データセット | uspto-grants-2010_08 |
| ORD ID | ord-7ad017e3cbfa4f3da88f8e255b9ba8ce |
| 出典メモ | uspto-grants-2010_08 |