Acetic Acid → HCID 57542158、化合物
反応式
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH:6][S:7]([C:10]1[CH:11]=[C:12]2[C:16](=[CH:17][CH:18]=1)[CH2:15][N:14](C(=O)C(Cl)(Cl)Cl)[CH2:13]2)(=[O:9])=[O:8].[OH-].[K+].C(O)(=O)C>CCO.O>[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH:6][S:7]([C:10]1[CH:11]=[C:12]2[C:16](=[CH:17][CH:18]=1)[CH2:15][NH:14][CH2:13]2)(=[O:9])=[O:8]参加物
6
実験手順
2-(2,2,2-Trichloro-acetyl)-2,3-dihydro-1H-isoindole-5-sulfonic acid thiazol-2-ylamide (0.10 g, 0.23 mmol) and KOH (0.03 g, 0.46 mmol) were stirred in a mixture of EtOH (0.5 mL) and H2O (0.13 mL) for 19 h at room temperature. The solution was acidified with acetic acid and concentrated in vacuo. The white solid was used in the next step without further purification. LC/MS (10-99% CH3CN), M/Z: M+1 obs=282.3; tR=2.62 min.
後処理
- concentrationconcentrated in vacuo
- customThe white solid was used in the next step without further purification
出典と根拠
- ORDレコード
- ord-d00ef63c66864ee5a27315feef33a073
- 出典データセット
- uspto-grants-2010_08
- 特許番号
- US07786137B2
反応ノート
読み込み中…