Cesium carbonate → 3-(3-Chloro-2-methyl-phenyl)-1-(2-pyrazolo[3,4-b]pyridin-1-yl-acetyl)-imidazolidin-4-one

HRID 507388ノート

反応式

HRID 507388 の反応式
Cl[CH2:2][C:3]([N:5]1[CH2:9][C:8](=[O:10])[N:7]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[C:12]=2[CH3:18])[CH2:6]1)=[O:4].[NH:19]1[C:23]2=[N:24][CH:25]=[CH:26][CH:27]=[C:22]2[CH:21]=[N:20]1.C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C=O)C.C(OCC)(=O)C>[Cl:17][C:13]1[C:12]([CH3:18])=[C:11]([N:7]2[C:8](=[O:10])[CH2:9][N:5]([C:3](=[O:4])[CH2:2][N:19]3[C:23]4=[N:24][CH:25]=[CH:26][CH:27]=[C:22]4[CH:21]=[N:20]3)[CH2:6]2)[CH:16]=[CH:15][CH:14]=1

参加物

6

反応物 3

HCID 10796Cesium carbonateHCID 27558501H-pyrazolo(3,4-b)pyridineHCID 594340271-(2-Chloro-acetyl)-3-(3-chloro-2-methyl-phenyl)-imidazolidin-4-one

生成物 1

HCID 594340293-(3-Chloro-2-methyl-phenyl)-1-(2-pyrazolo[3,4-b]pyridin-1-yl-acetyl)-imidazolidin-4-one

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 1-(2-Chloro-acetyl)-3-(3-chloro-2-methyl-phenyl)-imidazolidin-4-one (230 mg, 0.8 mmol, 1 eq), 1H-Pyrazolo[3,4-b]pyridine (96 mg, 0.8 mmol, 1 eq), Cesium carbonate (653 mg, 2.0 mmol, 2.5 eq) in DMF (6 ml) was stirred at room temperature overnight. It was diluted with ethyl acetate, washed with water and purified with HPLC to give the desired product. LCMS observed for (M+H)+: 370.1

後処理

  1. washwashed with water
  2. custompurified with HPLC

出典と根拠

ORDレコード
ord-1c490ec9cd434522aebc6fdfc121abb9
出典データセット
uspto-grants-2010_08
特許番号
US07786157B2

反応ノート

読み込み中…