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HRID 507398作成日：2026年10月26日
Potassium Carbonate → 4-[2-(2-Methyl-5-oxo-4,4-diphenyl4,5-dihydro-imidazol-1-yl)-acetyl]-benzoic acid ethyl ester
https://huagongshe.com/reaction/507398
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-methyl-4,4-diphenyl-1H-imidazol-5-one | HCID 619503 | — |
| 反応物 | Ethyl 4-(2-bromoacetyl)benzoate | HCID 11966043 | — |
| 反応物 | Cyclohexane ethylacetate | HCID 21867204 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 4-[2-(2-Methyl-5-oxo-4,4-diphenyl4,5-dihydro-imidazol-1-yl)-acetyl]-benzoic acid ethyl ester | HCID 68464053 | 48.1% |
反応手順
To a mixture of 4-(2-bromo-acetyl)-benzoic acid ethyl ester (812 mg, 3 mmol) and 2-methyl-5,5-diphenyl-3,5-dihydro-imidazol-4-one (750 mg, 3 mmol) in 12 mL acetone, potassium carbonate (502 mg, 3.6 mmol) is added and the reaction mixture is heated at 70° C. for 5 min in the microwave oven (Biotage Initiator). The mixture is cooled to room temperature, filtered and the filtrate evaporated to yield the crude product which is subjected to flash chromatography. ISCO Companion CombiFlash, 80 g silica gel, cyclohexane/ethyl acetate, gradient, ethyl acetate 0-100% to yield 4-[2-(2-methyl-5-oxo-4,4-diphenyl4,5-dihydro-imidazol-1-yl)-acetyl]-benzoic acid ethyl ester (635 mg, 45%) as light yellow solid. LC/MS at 254 nm; [M+H] 441; Rt 3.613 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07786155B2 |
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| 出典データセット | uspto-grants-2010_08 |
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| ORD ID | ord-f9d8a6508a3d42dbae724ee41ebb2115 |
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| 出典メモ | uspto-grants-2010_08 |
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