2-Bromobenzyl cyanide → 2-(4,4-Dimethyl2-oxo-1,4-dihydro-2H-benzo[d][1,3]-oxazin-6-yl)phenylacetonitrile

HRID 50747

反応式

HRID 50747 の反応式
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]#[N:10].[CH3:11][C:12]1([CH3:26])[C:17]2[CH:18]=[C:19](B(O)O)[CH:20]=[CH:21][C:16]=2[NH:15][C:14](=[O:25])[O:13]1>>[CH3:11][C:12]1([CH3:26])[O:13][C:14](=[O:25])[NH:15][C:16]2[CH:21]=[CH:20][C:19]([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=3[CH2:8][C:9]#[N:10])=[CH:18][C:17]1=2

参加物

3

反応物 2

HCID 296252-Bromobenzyl cyanideHCID 10987806(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)boronic acid

生成物 1

HCID 235096112-(4,4-Dimethyl2-oxo-1,4-dihydro-2H-benzo[d][1,3]-oxazin-6-yl)phenylacetonitrile

実験手順

Prepared according to procedure B from 2-bromophenylacetonitrile and (1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid. White solid, mp 176-179° C.; 1H-NMR (DMSO-d6), δ 10.31 (s, 1H), 7.53 (m, 1H), 7.48 (m, 2H), 7.22-7.32 (m, 3H), 6.98 (d, 1H; J=8.0 Hz), 3.90 (s, 2H), 1.64 (s, 6H). MS(+)APCI [M+H]+m/z=293. Anal. Calc. For C18H16N2O2: C, 73.95; H, 5.52; N, 9.58. Found: C, 73.51; H, 5.70; N, 9.39.

後処理

  1. customPrepared

出典と根拠

ORDレコード
ord-95c4cf808b1f41e183d21e61c6141e56
出典データセット
uspto-grants-2004_03
特許番号
US06713478B2

関連ノート

読み込み中…