N-(4-bromo-2-fluorophenyl)acetamide → N-[4-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)-2-fluorophenyl]-acetamide

HRID 50748

反応式

HRID 50748 の反応式
Br[C:2]1[CH:11]=[CH:10][C:5]([NH:6][C:7](=[O:9])[CH3:8])=[C:4]([F:12])[CH:3]=1.[CH3:13][C:14]1([CH3:28])[C:19]2[CH:20]=[C:21](B(O)O)[CH:22]=[CH:23][C:18]=2[NH:17][C:16](=[O:27])[O:15]1>>[CH3:13][C:14]1([CH3:28])[C:19]2[CH:20]=[C:21]([C:2]3[CH:11]=[CH:10][C:5]([NH:6][C:7](=[O:9])[CH3:8])=[C:4]([F:12])[CH:3]=3)[CH:22]=[CH:23][C:18]=2[NH:17][C:16](=[O:27])[O:15]1

参加物

3

反応物 2

HCID 67593N-(4-bromo-2-fluorophenyl)acetamideHCID 10987806(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)boronic acid

生成物 1

HCID 23509628N-[4-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)-2-fluorophenyl]-acetamide

実験手順

Prepared according to procedure B from 4′-bromo-2′-fluoroacetanilide and (1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid. Off white solid, mp 245-247° C. 1H-NMR (DMSO-d6) δ 10.3 (s, 1H), 9.79 (s, 1H), 7.95 (t, 1H, J=8.4 Hz), 7.56-7.63 (m, 3H), 7.47 (dd, 1H, J=1.64, 8.47 Hz), 6.95(d, 1H, J=8.9 Hz), 2.1 (s, 3H), 1.67 (s, 6H); MS+APCI [M+H]+m/z 329. Anal. Calc. For C18H17N2 FO3; C, 65.85; H, 5.22; N, 8.53. Found: C, 65.46; H, 5.24; N, 8.12.

後処理

  1. customPrepared

出典と根拠

ORDレコード
ord-d24c2822817d4911bca185e9654cd3a6
出典データセット
uspto-grants-2004_03
特許番号
US06713478B2

関連ノート

読み込み中…