Dimethylformamide dimethyl acetal → (E)-1-(1-benzothiophen-2-yl)-3-(dimethylamino)-2-propen-1-one

HRID 507529ノート

反応式

HRID 507529 の反応式
[S:1]1[C:5]([C:6](=[O:8])[CH3:7])=[CH:4][C:3]2[CH:9]=[CH:10][CH:11]=[CH:12][C:2]1=2.CO[CH:15](OC)[N:16]([CH3:18])[CH3:17]>>[S:1]1[C:5]([C:6](=[O:8])/[CH:7]=[CH:15]/[N:16]([CH3:18])[CH3:17])=[CH:4][C:3]2[CH:9]=[CH:10][CH:11]=[CH:12][C:2]1=2

参加物

3

反応物 2

HCID 78373Dimethylformamide dimethyl acetalHCID 898052-Acetylbenzothiophene

生成物 1

HCID 1491723(E)-1-(1-benzothiophen-2-yl)-3-(dimethylamino)-2-propen-1-one収率 84%

実験手順

A solution of 1-(benzo[b]thiophen-2-yl)ethanone (1 g) in dimethoxy-N,N-dimethyl-methanamine (10 mL) was refluxed for 6 h and then cooled to rt. The precipitate was filtered and washed with diethyl ether to afford the title compound (1.1 g, 84%).

後処理

  1. filtrationThe precipitate was filtered
  2. washwashed with diethyl ether

出典と根拠

ORDレコード
ord-f2a5fb2dd3df4d1d81e3f58468b126c1
出典データセット
uspto-grants-2010_08
特許番号
US07786132B2

反応ノート

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